Zainab Karem Mohammed Al-Taei, Maysoon Mustapha Jasim
College of Education for Pure Sciences, Tikrit University, Tikrit, Iraq
*Corresponding author: zainab@st.tu.edu.iq
Abstract
This study included 100 women, 75 women with recurrent miscarriages (one or more miscarriages) and 25 women without previous miscarriages and without any infection (control group), The study included a number of immunological tests, and these tests included estimation of the levels of immunoglobulins (immunoglobulin G and immunoglobulin M) for Toxoplasma gondii, and measuring the level of the hormones prolactin and progesterone, as well as measuring some cytokines (interleukin 27), The study showed that the prevalence of infection with Toxoplasma gondii parasite was the highest within the age groups (25-34 years), and it was found through the study that there was a significant increase in the concentration of IgG and IgM, as well as a significant difference in the level of prolactin hormone between infected and control women, The results of the statistical analysis at the 0.01 probability level showed that there were significant differences, as it was found that there was a decrease in the hormone prolactin amounted to (156.7 ± 29.4 ng/ml) in the infections compared to the control, while the progesterone hormone was not affected by the initiation of Toxoplasmosis, as it was found that there was a significant increase in the level of IL-27 amounting to (121.1 ± 29.2 pg/ml) in the infected compared with the control group. The study objectives also included the effect of toxoplasmosis on the level of antibodies, the level of hormones, and the level of IL-27, depending on the age groups. The study also showed the highest frequency of abortions in women who have had one recurrent miscarriage compared to those who have had two or three miscarriages.
Keywords Miscarriage, Immunological tests, Toxoplasmosis
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References
Abd-ul-Aziz, S. (2015). Sero-prevalence of anti-CMV-IgM and anti-CMV-IgG in Iraqi Aborted Women Infected with Human Cytomegalovirus in Nasiriyah city. University of Thi-Qar Journal, 10(4), 55-60.
Agrawal A., Singh S. K., Maheshwari R. K. and Goya J. K.(2016). Study of Serological Profile of Torch Infections in Women with Bad Obstetric History. Microbiology. 6 (5):2249-555X.
Ahmad, A. S., & Kareem, Y. K. (2020). Frequency of cytomegalovirus, rubella, and herpes simplex virus in embryonic tissues of women with missed abortion. Mosul Journal of Nursing, 8(1), 68-88.
Ahmed, R. I. (2017). Detection of Cytomegalovirus Infection in Pre-Marital Women in Al-Khalis City. Diyala Journal For Pure Science, 13(4-part 1).
AL-doury, S. N. M. (2018). Prevalence of Toxoplasma gondii, Cytomegalovirus and Rubella virus among aborted women in Samarra city. Tikrit Journal of Pure Science, 23(7), 32-35.
Al-Rawazq, H. S. A. M. (2017). Seroprevalence of Immunoglobulin G (IgG) and Immunoglobulin M (IgM) and Risk Factors of Toxoplasmosis for A sample of Pregnant Women in Baghdad. Al-Kindy College Medical Journal, 13(2), 40-45.
Al-Rawi, Z. A. (2019). Immunological and molecular diagnosis of Toxoplasmosis and the impact of infection on interleukin levels IL- 17, IL-8 and the third and fourth complement ,College of Education for pure sciences University of Tikrit The Degree of Master.
Al-shammary, R. N. (2014). Prevalence of Cytomegalovirus among pregnant women relation to congenital abnormalities in embryos and children in Wasit province .Journal of Kerbala University, 12(1).
Al-Taei, N. H., Al-Aboody, B. A., & Al-Temimi, M. B. (2015). Serological and immunological study to the prevalence of Toxoplasmosis among sewage workers, soil workers and sellers of fruits and vegetables in the province of Thi-Qar-Iraq. Journal of THI-QAR Science, 5(3).
Anwar, S. A. & Al-Bayati, N. S. (2018). Prevalence of Toxoplasma gondii and Cytomegalovirus in Sera of Aborted Women in Samaraa city. Tikrit Journal of Pure Science, 22(6), 34-38.
Balasundaram, M. B., Andavar, R., Palaniswamy, M. and Venkatapath, Y. N. (2010). Outbreak of acquired ocular toxoplasmosis involving 248 patients. Arch. Ophthalmol., 128(1):28-32.
Bedir, M. Alazawi., Farah, M. Sh. (2015). Studies on the effect of infected cases of parasite toxoplasma gondii on some sex hormones. Wor.j.ph.research.V.4,issus 10.2413-2423.
Belle, L., Agle, K., Zhou, V., Yin-Yuan, C., Komorowski, R., Eastwood, D. (2016). Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp 3 expression. Blood.128 (16):2068–2082.
Castro-Filice, L. S., Barbosa, B. F., Angeloni, M. B., Silva, N. M., Gomes, A. O., Alves, C. M., … & Ferro, E. A. (2014). Azithromycin is able to control Toxoplasma gondii infection in human villous explants. Journal of translational medicine, 12(1), 1-12.
Chiad, I. A. & Hama, A. A. (2019). Knowledge of Cytomegalic Inclusion Disease among a Sample of Pregnant Women in Baghdad City/Iraq. Al-Nisour Journal for Medical Sciences, 1(2).
Elizabeth, G. Gomez., Bertha, G. Pedrajo., Ignacio, C. Arroyo. (2013). Role of Sex Steroid Hormones in Bacterial-Host Interactions.Bio R International.Article ID 928290, pages 10
Émilie, B., Rajnish, Sh., Nicholas, B., Alvin, A. and Emily, J. (2017). Pathology, clinical signs, and tissue distribution of Toxoplasma gondii in experimentally infected reindeer (Rangifer tarandus). International Journal for Parasitology: Parasites and Wildlife . 6(3); 234-240.
Fitzgerald, D. C., Ciric, B., Touil, T., Harle, H., Grammatikopolou, J., Das Sarma, J., Gran, B., Zhang, G. X. and Rostami, A. (2007). Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of Thiqar province. Journal of education of college. 5(1):2-5.
Foitikova, M., Cerna, M., Paveika, K. (2010). A review of the effects of prolactin hormone and cytokine on the development and pathogenesis of autoimmune diseases. Na.int.of health. 56 (5): 402.13.
Hamoud, H. R., Al-Kashwan, T. A. J. & Tarish, H. R. (2021). Cytomegalovirus seropositivity among Iraqi women suffering from recurrent pregnancy loss. Al-Kufa University Journal for Biology, 13(1)
Hussein, A., Mohammed, A., and Rebah, N. (2014). seroprevalence of human cytomegalovirus (HCMV) in aborted women in Baghdad province. Int. J. Curr. Microbiol. App. Sci, 3(2): 97-102 .
Kadhim, R. A., & AL-awadi, H. M. (2013). Changes in testosterone, progesterone and prolactin levels in pregnant women with chronic toxoplasmosis. Medical Journal of Babylon, 10(3), 699-708.
kadhim, wael. dheaa. (2020). immunological profile of women with recurrent abortion due to microbial causes in thi-qar government, (master) of techology in medical laboratory science technology, middle technical university college of health and medical technology.
Kaur, K., Singh, M. & Virk, S. P. (2003) . prolactinomasin infertility . Rev . Gynaecol . pract 3: 180 – 187 . Speroff, L.; Glass, R. H.; Kase, N.G. (1999). Clinical Ginecologic Endocrinology and infertility, 6th Edn.Philadeiphia,PA: Lippincott Willians & Wilkins.1/70.
Khudhair, M. K., Mohammed, M. R. & Jassim, N. A. S. (2017). The Serologicalrates of Cytomegalovirus Among Women in Diyala Province, With a Study of Some The Immunological Markers. Diyala Journal For Pure Science, 13(3-part 3).
Mahfouz, M., Elmahdy, M., Bahri, A., Mobarki, Y., Altalhi, A., Barkat, N., Al-Essa, H., Ageely, A., Faqeeh, N., Areeshi, N. and Al-Hassan, S.(2019). Knowledge and attitude regarding toxoplasmosis among Jazan University female students. Saudi J Med Med Sci .7:28-32.
Mahmood, M. N. & Shareef, A. Y. (2019). Detection of infection by rubella and cytomegalovirus among women exposed to abortion in Ninavah province. Tikrit Journal of Pure Science, 24(1), 52-56.
Naji, N. A. & Tahrr, G. N. (2015). The effect of Activin A and Steroid Hormones on the Recurrent and single Abortion. Tikrit Journal of Pure Science, 20(5).
Paliwal, A., Agarwal, M. L., Chacko, K. M., Singh, A., Chauhan, A., & Jindal, T. (2017). Alteration in Physiological and Haematological profile of female albino wistar rats over 90 days oral repeated exposure by Fomesafen. Advances in Bioresearch, 8(5).
Paliwal, A., Agarwal, A. C. M., & Jindal, T. (2019). Fomesafen (diphenyl ether herbicide) toxicity in male albino wistar rats: physiological and biochemical assessment. Plant Archives, 19(2), 1881-1885.
Paliwal, A., Chauhan, A., Agarwal, M. L., & Jindal, T. (2019). Persistence of fomesafen herbicide residues in soybean crop. Plant Archives, 19(2), 1974-1979.
Shakir, O. M., Jasim, M. M. & Al-Abodi, H. R. J. (2020). Diagnosis of Toxoplasma gondii by Using ANA Test with Study of the Effect of the Parasite on Ceruloplasmin Enzyme. Journal of Cardiovascular Disease Research, 11(4), 141-145.
Speroff, L., Glass, R. H., Kase, N. G. (1999). Clinical Ginecologic Endocrinology andinfertility, 6th Edn.Philadeiphia,PA: Lippincott Willians & Wilkins.1/70.
Vas, R. S., Rauli, P., Mello, R. G. and Cardoso, M. A. (2011). Congenital toxoplasmosis: A Neglected Disease-Current Brazilian public health policy. Field actions science reports. Special Issue 3 Brazil.
Yoshida, H., Hunter, C. A. (2015). The immunobiology of interleukin-27. Annu Rev Immunol. 33:417–443.
Zamil, A. (2017). Study of the relationship between Toxoplasmosis disease and progesterone, Testosterone, Estradiol and Hormone Prolactin Among for abortion women in Diyala government. Diyala Journal For Pure Science, 13(1-part 1).
Zhou, P., Chen, Z., Li, H., Zheng, H. H., He, S., Lin, R. and Zhu, X. (2011). Toxoplasma gondii infection in humans in China. Parasites and Vectors, 4(165):1-9.
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